December 11 - Isaac Shelby born in Frederick County, Maryland.
- Isaac Shelby moves with his family to the Holston settlements.
- Isaac Shelby serves as a lieutenant in Lord Dunmore's War. October 10 - Isaac Shelby is present at action at Point Pleasant.
- Isaac Shelby serves as second in command at Fort Blair until June.
1776 July - Isaac Shelby is commissioned a Captain in the Virginia militia.
- Isaac Shelby is appointed commissary of supplies on the Virginia frontier. July 20 - Isaac Shelby attends the Long Island Treaty at Fort Patrick Henry.
- Isaac Shelby is appointed commissary of supplies for the Continental Army in expeditions against the Northwest Indians.
- Isaac Shelby was elected to the Virginia Legislature from Washington County.
- Isaac Shelby is commissioned a Major by Virginia Governor Thomas Jefferson.
- Isaac Shelby is commissioned a Lieutenant by North Carolina Governor Caswell. July 20 - Isaac Shelby captures Tory fortifications at the Pacelot River. August 18 - Isaac Shelby shares command at Musgrove's Mill. October 7 - Isaac Shelby shares command at the Battle of King's Mountain, North Carolina.
- Isaac Shelby moves to the territory of Kentucky.
1783 April - Isaac Shelby marries Susannah Hart.
- Isaac Shelby settles in Lincoln County and becomes county High Sheriff and surveyor.
- Isaac Shelby becomes one of the first trustees of the Transylvania Seminary.
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